Publications & Patents

456. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century, K.C. Nicolaou, D. Vourloumis, N. Winssinger, P.S. Baran, Angew. Chem. Int. Ed. 2000, 39, 44–122.

457. Solid-Phase Combinatorial Synthesis Using MicroKan Reactors, Rf Tagging, and Directed Sorting, X.-Y. Xiao, R. Li, H. Zhuang, B. Ewing, K. Karunaratne, J. Lillig, R. Brown, K.C. Nicolaou, Biotechnol. Bioengin. (Combinatorial Chemistry) 2000, 71, 44–50.

458. New Synthetic Technology for the Rapid Construction of Novel Heterocycles. 1. The Reaction of Dess–Martin Periodinane with Anilides and Related Compounds, K.C. Nicolaou, Y.-L. Zhong, P.S. Baran, Angew. Chem. Int. Ed. 2000, 39, 622–625.

459. New Synthetic Technology for the Rapid Construction of Novel Heterocycles. 2. The Reaction of IBX with Anilides and Related Compounds, K.C. Nicolaou, Y.-L. Zhong, P.S. Baran, Angew. Chem. Int. Ed. 2000, 39, 625–628.

460. Selenium-Based Solid-Phase Synthesis of Benzopyrans I: Applications to Combinatorial Synthesis of Natural Products, K.C. Nicolaou, J.A. Pfefferkorn, G.-Q. Cao, Angew. Chem. Int. Ed. 2000, 39, 734–739.

461. Selenium-Based Solid-Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules, K.C. Nicolaou, J.A. Pfefferkorn, G.-Q. Cao, Angew. Chem. Int. Ed. 2000, 39, 739–743.

462. Synthesis of the Macrocyclic Core of Apoptolidin, K.C. Nicolaou, Y. Li, B. Weyerhausen, H. Wei, Chem. Commun. 2000, 307–308.

463. New Selenium-Based Safety-Catch Linkers.  Solid-Phase Semisynthesis of Vancomycin, K.C. Nicolaou, N. Winssinger, R. Hughes, C. Smethurst, S.Y. Cho, Angew. Chem. Int. Ed. 2000, 39, 1084–1088.

464. 1,2-Seleno Migrations in Carbohydrate Chemistry: Solution and Solid-Phase Synthesis of 2-Deoxy Glycosides, Orthoesters, and Allyl Orthoesters, K.C. Nicolaou, H.J. Mitchell, K.C. Fylaktakidou, H. Suzuki, R. Rodriguez, Angew. Chem. Int. Ed. 2000, 39, 1089–1093.

465. Solution and Solid-Phase Synthesis of Functionalized 3-Arylbenzofurans by a Novel Cyclofragmentation - Release Pathway, K.C. Nicolaou, S.A Snyder, A. Bigot, J. Pfefferkorn, Angew. Chem. Int. Ed. 2000, 39, 1093–1096.

466. A Common Pharmacophore for Epothilones and Taxol: Molecular Basis for Drug Resistance-Conferred by Tubulin Mutations in Human Cancer Cells, P. Giannakakou, R. Gussio, E. Nogales, K.H. Downing, D. Zaharevitz, B. Bollbuck, G. Poy, D. Sackett, K.C. Nicolaou, T. Fojo, Proc. Natl. Acad. Sci. USA 2000, 97, 2904–2909.

467. A Novel Strategy for the Solid Phase Synthesis of Substituted Indolines, K.C. Nicolaou, A.J. Roecker, J.A. Pfefferkorn, G.-Q. Cao, J. Am. Chem. Soc. 2000, 122, 2966–2967.

468. Biomimetic Total Synthesis of Bisorbicillinol, Bisorbitutenolide, Trichodimerol, and Designed Analogues of the Bisorbicillinoids, K.C. Nicolaou, G. Vassilikogiannakis, K.B. Simonsen, P.S. Baran, Y.-L. Zhong, V.P. Vidali, E.N. Pitsinos, E.A. Couladouros, J. Am. Chem. Soc. 2000, 122, 3071–3079.

469. Total Synthesis of the Immunosuppressant Sanglifehrin A, K.C. Nicolaou, F. Murphy, S. Barluenga, T. Ohshima, H.Wei, J. Xu, D.L.F. Gray, O. Baudoin, J. Am. Chem. Soc. 2000, 122, 3830–3838.

470. The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A), K.C. Nicolaou, J.-K. Jung, W.H. Yoon, Y. He, Y.-L. Zhong, P.S. Baran, Angew. Chem. Int. Ed. 2000, 39, 1829–1832.

471. New Synthetic Technology for the Mild and Selective One-Carbon Homologation of Hindered Aldehydes in the Presence of Ketones, K.C. Nicolaou, G. Vassilikogiannakis, R. Kranich, P.S. Baran, Y.-L. Zhong, S. Natarajan, Org. Lett. 2000, 2, 1895–1898.

472. High Throughput Combinatorial Synthesis of Discrete Compounds in Multimilligram Quantity: Non-chemical Encoding and Directed Sorting, X.-Y. Xiao, K.C. Nicolaou, in Combinatorial Chemistry- A Practical Approach, Hicham Fenniri, Ed., Oxford University Press, New York, 2000, pp. 75–93.

473. Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof, K.C. Nicolaou, P.S. Baran, Y.-L. Zhong, J.A. Vega, Angew. Chem. Int. Ed. 2000, 39, 2525–2529.

474. Novel Reactions Initiated by Titanocene Methylidenes: Deoxygenation of Sulfoxides, N–Oxides, and Selenoxides, K.C. Nicolaou, A.E. Koumbis, S.A. Snyder, K.B. Simonsen, Angew. Chem. Int. Ed. 2000, 39, 2529–2533.

475. Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues, K.C. Nicolaou, D. Hepworth, N.P. King, M.R.V. Finlay, R. Scarpelli, M.M.A. Pereira, B. Bollbuck, A. Bigot, B. Werschkun, N. Winssinger, Chem. Eur. J. 2000, 6, 2783–2800.

476. A New Method for the One-Step Synthesis of α, β-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds, K.C. Nicolaou, Y.-L. Zhong, P.S. Baran, J. Am. Chem. Soc. 2000, 122, 7596–7597.

477. Chemical Synthesis and Biological Properties of Pyridine Epothilones, K.C. Nicolaou, R. Scarpelli, B. Bollbuck, B. Werschkun, M.M.A. Pereira, M. Wartmann, K.-H. Altmann, D. Zaharevitz, R. Gussio, P. Giannakakou, Chem. Biol. 2000, 7, 593–599.

478. Total Synthesis of Everninomicin 13,384-1. Part 1: Retrosynthetic Analysis and Synthesis of the A1B(A)C Fragment, K.C. Nicolaou, R.M. Rodríguez, H.J. Mitchell, H. Suzuki, K.C. Fylaktakidou, O. Baudoin, F.L. van Delft, Chem. Eur. J. 2000, 6, 3095–3115.

479. Total Synthesis of Everninomicin 13,384-1. Part 2: Synthesis of the FGHA2 Fragment, K. C. Nicolaou, H.J. Mitchell, K.C. Fylaktakidou, R.M. Rodríguez, H. Suzuki, Chem. Eur. J. 2000, 6, 3116–3148.

480. Total Synthesis of Everninomicin 13,384-1. Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis, K.C. Nicolaou, H.J. Mitchell, R.M. Rodríguez, K.C. Fylaktakidou, H. Suzuki, S.R. Conley, Chem. Eur. J. 2000, 6, 3149–3165.

481. Total Synthesis of Everninomicin 13,384-1. Part 4: Explorations of Methodology. Stereocontrolled Synthesis of 1,1'-Disaccharides, 1,2-Seleno Migrations in Carbohydrates, and Solution and Solid Phase Synthesis of 2-Deoxy Glycosides and Orthoesters, K.C. Nicolaou, K.C. Fylaktakidou, H.J. Mitchell, F.L. van Delft, R.M. Rodríguez, S.R. Conley, Z. Jin, Chem. Eur. J. 2000, 6, 3166–3185.

482. Total Synthesis and Biological Evaluation of Glycolipids Plakosides A, B and Their Analogs, K.C. Nicolaou, J. Li, G. Zenke, Helv. Chim. Acta 2000, 83, 1977–2006.

483. Model Studies Towards Diazonamide A: Synthesis of the Heterocyclic Core, K.C. Nicolaou, S.A. Snyder, K.B. Simonsen, K.E. Koumbis, Angew. Chem. Int. Ed. 2000, 39, 3473–3478.

484. Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1.  General Principles and Solid-Phase Synthesis of Benzopyrans, K.C. Nicolaou, J.A. Pfefferkorn, A.J. Roecker, G.-Q. Cao, S. Barluenga, H.J. Mitchell, J. Am. Chem. Soc. 2000, 122, 9939–9953.

485. Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10,000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding, K.C. Nicolaou, J.A. Pfefferkorn, H.J. Mitchell, A.J. Roecker, S. Barluenga, G.-Q. Cao, R.L. Affleck, J.E. Lillig, J. Am. Chem. Soc. 2000, 122, 9954–9967.

486. Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3.  The "Libraries from Libraries" Principle for Diversity Enhancement of Benzopyran Libraries, K.C. Nicolaou, J.A. Pfefferkorn, S. Barluenga, H.J. Mitchell, A.J. Roecker, G.-Q. Cao, J. Am. Chem. Soc. 2000, 122, 9968–9976.

487. Novel Solution- and Solid-Phase Chemistry of a-Sulfonated Ketones Applicable to Combinatorial Chemistry, K.C. Nicolaou, P.S. Baran, Y.-L. Zhong, J. Am. Chem. Soc. 2000, 122, 10246–10248.

488. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective against Vancomycin-Resistant Bacteria, K.C. Nicolaou, R. Hughes, S.-Y. Cho, N. Winssinger, C. Smethurst, H. Labischinski, R. Endermann, Angew. Chem. Int. Ed. 2000, 39, 3823–3828.

489. New Roads to Molecular Complexity, K.C. Nicolaou, E.W. Yue, in The New Chemistry, Nina Hall, Ed., Cambridge University Press, Cambridge, UK, Ch. 8, 2000, pp. 168–198.

490. Combinatorial Synthesis of Novel and Potent Inhibitors of NADH: Ubiquinone Oxidoreductase, K.C. Nicolaou, J.A. Pfefferkorn, F. Schuler, A.J. Roecker, G.-Q. Cao, J.E. Casida, Chem. Biol. 2000, 7, 979–992.

491. Synthesis and Biological Evaluation of 12,13-Cyclopropyl and 12,13-Cyclob