Publications & Patents

67.  Phenylselenoetherification.  A Highly Efficient Cyclization Process for the Synthesis of O- and S-Heterocycles, K.C. Nicolaou, R.L. Magolda, W.J. Sipio, W.E. Barnette, Z. Lysenko, M.M. Joullié, J. Am. Chem. Soc. 1980, 102, 3784–3793.

68. A Remarkably Simple, Highly Efficient and Stereoselective Synthesis of Steroids and Other Polycyclic Systems. Total Synthesis of Estra-1,3,5(10)-trien-17-one via Intramolecular Capture of o-Quinodimethanes Generated by Cheletropic Elimination of SO2, K.C. Nicolaou, W.E. Barnette, P. Ma, J. Org. Chem. 1980, 45, 1463–1470.

69. Carbocyclic Thromboxane A2 (CTA2), K.C. Nicolaou, R.L. Magolda, D.A. Claremon, J. Am. Chem. Soc. 1980, 102, 1404–1409.

70. Prostaglandin Endoperoxides, Thromboxanes and Prostacyclins.  Prostanoids with Important Biological Properties and Significant Chemical Interest, K.C. Nicolaou, N.A. Petasis, Chimika Chronika, General Ed. 1980, 45, 43–51 (Review in Greek).

71. Total Synthesis of (±)-Zoapatanol, K.C. Nicolaou, D.A. Claremon, W.E. Barnette, J. Am. Chem. Soc. 1980, 102, 6611–6612.

72. Synthesis and Biological Properties of Prostacyclins, K.C. Nicolaou, W.E. Barnette, R.L. Magolda, in Prostaglandins in Cardiovascular and Renal Function, Spectrum Publications, Inc., New York, 1980, pp. 9–28.

73. Prostacyclin Has Effects on Proximal and Distal Tubular Function in the Dog, H.-G. Gullner, K.C. Nicolaou, F.C. Bartter, Prostaglandins and Medicine 1980, 6, 141–146.

74. Dissociation of Vasoconstrictor and Platelet Aggregatory Activities of Thromboxanes by Carbocyclic Thromboxane A2 (CTA2), a New Stable Analog of Thromboxane A2 (TA2), A.M. Lefer, E.F. Smith, III, H. Araki, J.B. Smith, D. Aharony, D.A. Claremon, R.L. Magolda, K.C. Nicolaou, Proc. Natl. Acad. Sci. USA 1980, 77, 1706–1710.

75. In Vivo Release and Turnover of Secreted Platelet Antiheparin Proteins in Rhesus Monkey (M. Mulatta), J. Musial, S. Niewiarowski, L.H. Edmunds, Jr., V.P. Addonizio, Jr. K.C. Nicolaou, R.W. Colman, Blood 1980, 56, 596–603.

76. Effect of Prostacyclin (PGI2) on Renal Function and Renin Secretion in Hypophysectomized Dogs, H.-G. Gullner, K.C. Nicolaou, F.C. Bartter, G. Kelly, Nephron 1980, 25, 283–287.

77. PGI2-Specific Antibodies Administered In Vivo Suggest Against a Role for Endogenous PGI2 as a Circulating Vasodepressor Hormone in the Normotensive and Spontaneously Hypertensive Rat, C.R. Pace-Asciak, M.C. Carrara, L. Levine, K.C. Nicolaou, Prostaglandins 1980, 20, 1053–1060.

78. Preservation of the Ischemic Myocardium by Pinane Thromboxane A2, K. Schror, E.F. Smith, III. M. Bickerton, J.B. Smith, R.L. Magolda, K.C. Nicolaou, A.M. Lefer, Am. J. Physiol. 1980, 238, H87–H92.

79. Organoselenium-Based Synthesis of Oxygen-Containing Prostacyclins, K.C. Nicolaou, W.E. Barnette, R.L. Magolda, J. Am. Chem. Soc. 1981, 103, 3480–3485.

80. Organoselenium-Based Synthesis of Sulfur-Containing Prostacyclins, K.C. Nicolaou, W.E. Barnette, R.L. Magolda, J. Am. Chem. Soc. 1981, 103, 3486–3497.

81. Synthesis of 16-Membered Ring Macrolide Antibiotics 3.  Carbomycin B and Leucomycin A3:  Retrosynthetic Studies, K.C. Nicolaou, S.P. Seitz, M.R. Pavia, J. Am. Chem. Soc. 1981, 103, 1222–1224.

82. Synthesis of 16-Membered Ring Macrolide Antibiotics 4.  Carbomycin B and Leucomycin A3:  Synthesis of Key Intermediate, K.C. Nicolaou, M.R. Pavia, S.P. Seitz, J. Am. Chem. Soc. 1981, 103, 1224–1226.

83. Ionophore Antibiotic X-14547A.  Degradation Studies and Stereoselective Construction of the "Left Wing" (C11-C25 Fragment) by an Intramolecular Diels–Alder Reaction, K.C. Nicolaou, R.L. Magolda, J. Org. Chem. 1981, 46, 1506–1508.

84. Synthesis of 5Z- and 5E-6,9-Thiaprostacyclins, K.C. Nicolaou, W.E. Barnette and R.L. Magolda, J. Am. Chem. Soc. 1981, 103, 3472–3480.

85. Total Synthesis of Ionophore Antibiotic X-14547A.  1. Enantioselective Synthesis of the Tetrahydropyran and Tetrahydroindan Building Blocks, K.C. Nicolaou, D.P. Papahatjis, D.A. Claremon, R.E. Dolle, III, J. Am. Chem. Soc. 1981, 103, 6967–6969.

86. Total Synthesis of Ionophore Antibiotic X-14547A.  2.  Coupling of the Tetrahydropyran and Tetrahydroindan Systems and Construction of the Butadienyl and Ketopyrrole Moieties, K.C. Nicolaou, D.A. Claremon, D.P. Papahatjis, R.L. Magolda, J. Am. Chem. Soc. 1981, 103, 6969–6971.

87. N-Phenylselenophthalimide.  A Useful Reagent for the Facile Transformation of (1) Carboxylic Acids into Either Selenol Esters or Amides and (2) Alcohols into Alkyl Phenyl Selenides, P.A. Grieco, J.Y. Jaw, D.A. Claremon, K.C. Nicolaou, J. Org. Chem. 1981, 46, 1215–1217.

88. An Expeditious and Efficient Entry into the Aphidicolin and Related Natural Products Ring Skeleton, K.C. Nicolaou, R. Zipkin, Angew. Chem. Int. Ed. Engl. 1981, 20, 785–786.

89. A Mild Method for the Synthesis of 2-Ketopyrroles from Carboxylic Acids, K.C. Nicolaou, D.A. Claremon, D.P. Papahatjis, Tetrahedron Lett. 1981, 22, 4647–4650.

90. 5,6-Methanoleukotriene A4.  A Stable and Biologically Active Analogue of Leukotriene A4.  K.C. Nicolaou, N.A. Petasis, S.P. Seitz, J. Chem. Soc., Chem. Commun. 1981,1195–1196.

91. Spasmogenic Effects of the Anti-Fertility Agent Zoapatanol, K.B. Smith, E.F. Smith, III, A.M. Lefer, K.C. Nicolaou, Life Sciences 1981, 28, 2743–2746.

92. Mechanism of Coronary Vasoconstriction Induced by Carbocyclic Thromboxane A2, E.F. Smith, A.M. Lefer, K.C. Nicolaou, Am. J. Physiol. 1981, 240, H493–H497.

93. Carbocyclic Thromboxane A2:  Aggrevation of Myocardial Ischemia by a New Synthetic Thromboxane A2 Analog, E.F. Smith, III, A.M. Lefer, D. Aharony, J.B. Smith, R.L. Magolda, D.A. Claremon, K.C. Nicolaou, Prostaglandins 1981, 21, 443–456.

94. Organoselenium-Induced Cyclizations in Organic Synthesis, K.C. Nicolaou, Tetrahedron Symposia in Print 1981, 37, 4097–4109.

95. Agonist-Specific Desensitization of Prostaglandin-Stimulated Cyclic AMP Accumulation in Palatal Mesenchymal Cells, R.M. Greene, L.A. Verbruggen, M.R. Lloyd, K.C. Nicolaou, J. Craniofacial Genet. Dev. Biol. 1981, 1, 261–272.

96. Thromboxane Synthetase Inhibitors Differentially Antagonize Thromboxane Receptors in Vascular Smooth Muscle, E.F. Smith, III, A.M. Lefer, J.B. Smith, K.C. Nicolaou, Naunyn-Schmiedeberg's Archives of Pharmacology 1981, 318, 130–134.

97. Cardiovascular Actions of Two Thromboxane A2 Analogs, A.M. Lefer, J.B. Smith, K.C. Nicolaou, in Adv. in Physiol. Sci., Cardiovascular Physiology:  Micro Circulatory and Capillary Exchange, A.G.B. Kovach, J. Hamar, L. Szabo, Eds., Pergamon Press, London, Vol. 7, 1981, pp. 91–98.

98. Synthesis of Stable Thromboxane A2 Analogs:  Pinane Thromboxane A2 Analogs:  Pinane Thromboxane A2 (PTA2) and Carbocyclic Thromboxane A2 (CTA2), K.C. Nicolaou, R.L. Magolda, in Methods in Enzymology, W.E.M. Lands and W.L. Smith, Eds., Academic Press, New York, Vol. 86, 1982, pp. 400–409.

99. Anti-Thromboxane A2 Action of Pinane Thromboxane A2 Derivatives, D.M. Roth, A.M. Lefer, J.B. Smith, K.C. Nicolaou, Prostaglandins, Leukotrienes and Medicine 1982, 9, 503–509.

100. Carbohydrates in Organic Synthesis.  Synthesis of 16-Membered Ring Macrolide Antibiotics. 5. Total Synthesis of O-Mycinosyl Tylonolide:  Synthesis of Key Intermediates, K.C. Nicolaou, M.R. Pavia, S.P. Seitz, J. Am. Chem. Soc. 1982, 104, 2027–2029.

101. Carbohydrates in Organic Synthesis.  Synthesis of 16-Membered Ring Macrolide Antibiotics. 6. Total Synthesis of O-Mycinosyl Tylonolide:  Coupling of Key Intermediate and Macrocyclization, K.C. Nicolaou, S.P. Seitz, M.R. Pavia, J. Am. Chem. Soc. 1982, 104, 2030–2031.

102. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis.  1. Stepwise, Stereocontrolled Total Synthesis of Endiandric Acids A and B, K.C. Nicolaou, N.A. Petasis, R.E. Zipkin, J. Uenishi, J. Am. Chem. Soc. 1982, 104, 5555–5557.

103. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis.  2. Stepwise, Stereocontrolled Total Synthesis of Endiandric Acids C-G, K.C. Nicolaou, N.A. Petasis, J. Uenishi, R.E. Zipkin, J. Am. Chem. Soc. 1982, 104, 5557–5558.

104. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis.  3. "Biomimetic" Approach to Endiandric Acids A-G.  Synthesis of Precursors, K.C. Nicolaou, R.E. Zipkin, N.A. Petasis, J. Am. Chem. Soc. 1982, 104, 5558–5560.

105. The Endiandric Acid Cascade. Electrocyclizations in Organic Synthesis.  4. "Biomimetic" Approach to Endiandric Acids A-G.  Total Synthesis and Thermal Studies, K.C. Nicolaou, N.A. Petasis, R.E. Zipkin, J. Am. Chem. Soc. 1982, 104, 5560–5562.

106. Selective Inhibition of 5-Lipoxygenase by 5,6-Methanoleukotriene A4, A Stable Analogue of Leukotriene A4, Y. Koshihara, S.-I. Murota, N.A. Petasis, K.C. Nicolaou, FEBS Lett. 1982, 143, 13–16.

107. Stereocontrolled Synthesis of 1,3,5...2n+1 Polyols, K.C. Nicolaou, J. Uenishi, J. Chem. Soc., Chem. Commun. 1982, 1292–1293.

108. Chemistry and Pharmacology of a Series of New Thromboxane Analogs, K.C. Nicolaou, J.B. Smith, A.M. Lefer, Drugs of the Future 1982, VII 331–340.

109. 5,6-Methano Leukotriene A4:  A Potent Specific Inhibitor for 5-Lipoxygenase, Y. Koshihara, S. Murota, K.C. Nicolaou, in Advances in Prostaglandin, Thromboxane and Leukotriene Research, B. Samuelsson, R. Paoletti, P.W. Ramwell, Eds., Raven Press, New York, Vol. 11, 1983, pp. 163–167.

110. A Mild and General Method for the Synthesis of O-Glycosides, K.C. Nicolaou, S.P. Seitz, D.P. Papahatjis, J. Am. Chem. Soc. 1983, 105, 2430–2434.

111. Responsiveness of Platelets and Coronary Arteries from Different Species to Synthetic Thromboxane and Prostaglandin Endoperoxide Analogs, S.E. Burke, A.M. Lefer, K.C. Nicolaou, G.M. Smith, J.B. Smith, Br. J. Pharm. 1983, 78, 287–294.

112. Ethanoarachidonic Acids.  A New Class of Arachidonic Acid Cascade Modulators 1. Monoethanocompounds, K.C. Nicolaou, N.A. Petasis, W.S. Li, T. Ladduwahetty, J.L. Randall, S.E. Webber, P.E. Hernandez, J. Org. Chem. 1983, 48, 5400–5403.

113. Ethanoarachidonic Acids.  A New Class of Arachidonic Acid Cascade Modulators 2. Polyethanocompounds, K.C. Nicolaou, P.E. Hernandez, T. Ladduwahetty, J.L. Randall, S.E. Webber, W.S. Li, N. A. Petasis, J. Org. Chem. 1983, 48, 5403–5404.

114. Pericyclic Reactions in Organic Synthesis and Biosynthesis.  Synthetic Adventures with Endiandric Acids A-G, K.C. Nicolaou, N.A. Petasis, in Strategies and Tactics of Organic Synthesis, T. Lindberg, Ed., Academic Press, New York, Ch. 6, 1984, pp. 155–173.

115. Total Synthesis of the Potent Mutagen (S)-3-(1,3,5,7,9-Dodecapentanyloxy)-1,2-propanediol, K.C. Nicolaou, R. Zipkin, D. Tanner, J. Chem. Soc., Chem. Commun. 1984, 349–350.

116. Synthesis of 7,13-Bridged Arachidonic Acid Analogs, K.C. Nicolaou, S. Webber, J. Chem. Soc., Chem. Commun. 1984,350–351.

117. A General and Stereocontrolled Total Synthesis of Leukotriene B4 and Analogs, K.C. Nicolaou, R.E. Zipkin, R.E. Dolle, B.D. Harris, J. Am. Chem. Soc. 1984, 106, 3548–3551.

118. A Practical Synthesis of Oligosaccharides. Partial Synthesis of Avermectin B1a, K.C. Nicolaou, R.E. Dolle, D.P. Papahatjis, J.L. Randall, J. Am. Chem. Soc. 1984, 106, 4189–4192.

119. Reactions of 2,3-Epoxyhalides.  Synthesis of Optically Active Allylic Alcohols and Homoallylic Epoxides, K.C. Nicolaou, M.E. Duggan, T. Ladduwahetty, Tetrahedron Lett. 1984, 25, 2069–2072.

120. Reactions of Hydroxyl Groups with Tosylchloride-Dimethylaminopyridine System.  Direct Synthesis of Chlorides from Hydroxycompounds, C.K. Hwang, W.S. Li, K.C. Nicolaou, Tetrahedron Lett. 1984, 25, 2295–2296.

121. Reactions of Glycosyl Fluorides.  Synthesis of C-Glycosides, K.C. Nicolaou, R.E. Dolle, A. Chucholowski, J.L. Randall, J. Chem. Soc., Chem. Commun. 1984, 1153–1154.

122. Reactions of Glycosyl Fluorides.  Synthesis of O-, S- and N-Glycosides, K.C. Nicolaou, A. Chucholowski, R.E. Dolle, J.L. Randall, J. Chem. Soc., Chem. Commun. 1984,1155–1156.

123. Total Synthesis of 5(S), 15(S)-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic Acid (5,15-DiHETE), and 8(S), 15(S)-Dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic Acid (8,15-DiHETE):  Two Novel Metabolites of Arachidonic Acid, K.C. Nicolaou, S.E. Webber, J. Am. Chem. Soc. 1984, 106, 5734–5736.

124. Total Synthesis of Elfamycins Aurodox and Efrotomycin.  1. Strategy and Construction of Key Intermediates, R.E. Dolle, K.C. Nicolaou, J. Am. Chem. Soc. 1985, 107, 1691–1694.

125. Total Synthesis of Elfamycins Aurodox and Efrotomycin.  2. Coupling of Key Intermediates and Completion of the Synthesis, R.E. Dolle, K.C. Nicolaou, J. Am. Chem. Soc. 1985, 107, 1695–1698.

126. A General Strategy for the Total Synthesis of the Presumed Lipoxin Structures, K.C. Nicolaou, S.E. Webber, J. Chem. Soc., Chem. Commun. 1985,297–298.

127. An Intramolecular Diels–Alder Approach to Forskolin, K.C. Nicolaou, W.S. Li, J. Chem. Soc., Chem. Commun. 1985,421.

128. Total Synthesis of Ionophore Antibiotic X-14547A, K.C. Nicolaou, D.P. Papahatjis, D.A. Claremon, R.L. Magolda, R.E. Dolle, J. Org. Chem. 1985, 50, 1440–1456.

129. Modulation of Leukotriene Synthesis and Actions by Synthetic Derivatives of Arachidonic Acid, J.B. Smith, D.M. Roth, A.M. Lefer, N.A. Petasis, K.C. Nicolaou, Prostaglandins 1985, 29, 765–771.

130. Modern Synthetic Technology and Total Synthesis of Bioactive Molecules, K.C. Nicolaou, N.A. Petasis, R.E. Dolle, III, W.S. Li, D.P. Papahatjis, J. Uenishi, R.E. Zipkin, in New Methods in Drug Research, A. Makriyannis, Ed., J.R. Prous Science, Barcelona, Ch. 11, 1985, pp. 179–200.

131. Carbohydrate-Based Syntheses of the Goldinolactone and the Tetrahydrofuran Fragments of Aurodox and Efrotomycin, R.E. Dolle, K.C. Nicolaou, J. Chem. Soc., Chem. Commun. 1985,1016–1018.

132. New Synthetic Technology and Total Synthesis. The Elfamycins, K.C. Nicolaou, Chem. Br. 1985, 813–817.

133. Activation of 6-Endo over 5-Exo Epoxide Openings.  Ring Selective Formation of Tetrahydropyran Systems and Stereocontrolled Synthesis of the ABC Ring Framework of Brevetoxin B, K.C. Nicolaou, M.E. Duggan, C.-K. Hwang, P.K. Somers, J. Chem. Soc., Chem. Commun. 1985,1359–1362.

134. Stereospecific Synthesis of Rhynchosporosides: A Family of Fungal Metabolites Causing Scald Disease in Barley and Other Grasses, K.C. Nicolaou, J.L. Randall, G.T. Furst, J. Am. Chem. Soc. 1985, 107, 5556–5558.

135. N-Phenylselenophthalimide (NPSP):  A Valuable Selenenylating Agent, K.C. Nicolaou, N.A. Petasis, D.A. Claremon, Tetrahedron 1985, 41, 4835–4841.

136. Stereocontrolled Total Synthesis of (5Z, 8Z, 11Z, 13E) (15S)-15-Hydroxyeicosa-5,8,11,13-tetraenoic Acid (15S-HETE) and Analogues, K.C. Nicolaou, T. Ladduwahetty, E.M. Elisseou, J. Chem. Soc., Chem. Commun. 1985,1580–1581.

137. Stereocontrolled Total Synthesis of Lipoxins A, K.C. Nicolaou, C.A. Veale, S.E. Webber, H. Katerinopoulos, J. Am. Chem. Soc. 1985, 107, 7515–7518.

138. Total Synthesis of 20-Hydroxy- and 20-Carboxy-Leukotrienes B4, K.C. Nicolaou, Y.S. Chung, P.E. Hernandez, I.M. Taffer, R.E. Zipkin, Tetrahedron Lett. 1986, 27, 1881–1882.

139. Retrosynthetic and Synthetic Chemistry of Amphotericin B.  Synthesis of C1-C10   and C21-C38  Fragments and Construction of the 38-Membered Macrocycle, K.C. Nicolaou, T.K. Chakraborty, R.A. Daines, N.S. Simpkins, J. Chem Soc., Chem. Commun. 1986,413–416.

140. Stereospecific 1,2-Migrations in Carbohydrates. Stereocontrolled Synthesis of a- and b-2-Deoxyglycosides, K.C. Nicolaou, T. Ladduwahetty, J.L. Randall, A. Chucholowski, J. Am. Chem. Soc. 1986, 108, 2466–2467.

141. New Synthetic Technology for the Construction of Oxocenes, K.C. Nicolaou, M.E. Duggan, C.-K. Hwang, J. Am. Chem. Soc. 1986, 108, 2468–2469.

142. A General Strategy for the Synthesis of Monohydroxy-eicosatetraenoic Acids:  Total Synthesis of 5(S)-Hydroxy-6(E),8,11,14(Z)-eicosatetraenoic Acid (5-HETE) and 12(S)-Hydroxy-5,8,14(Z)-10(E)-eicosatetraenoic Acid (12-HETE), K.C. Nicolaou, T. Ladduwahetty, I.M. Taffer, R.E. Zipkin, Synthesis 1986, 344–347.

143. Organic Chemistry Today and Tomorrow, K.C. Nicolaou, N.A. Petasis, Chimika Chronika, General Ed. 1986, 51, 411–429 (Review in Greek).

144. Stereocontrolled Total Synthesis of Lipoxins B, K.C. Nicolaou, S.E. Webber, Synthesis 1986, 453–461.

145. Coronary Vasoactivity of Four 7,13-Bridged Analogs of Arachidonic Acid, A. Yanagisawa, M. Brezinshi, A.M. Lefer, S.E. Webber, K.C. Nicolaou, Prostaglandins, Leukotrienes and Medicine 1986, 23, 15–19.

146. Stereospecific Synthesis of 1,1-Dialkylglycosides, K.C. Nicolaou, C.-K. Hwang, M.E. Duggan, J. Chem. Soc., Chem. Commun. 1986,925–926.

147. Synthesis and Vascular Actions of an Arachidonic Acid Ethylene-Diamino-Triethyl-Ester (AA-EDTA) Derivative, A. Yanagisawa, A.M. Lefer, M.E. Elisseou, K.C. Nicolaou, Prostaglandins 1986, 31, 1063–1068.

148. Lipoxin A:  Stereochemistry and Biosynthesis, C.N. Serhan, K.C. Nicolaou, S.E. Webber, C.A. Veale, S.-E. Dahlen, T.J. Puustinen, B. Samuelsson, J. Biol. Chem. 1986, 261, 16340–16345.

149. Bridging of Macrocycles to Bicycles.  New Synthetic Technology for the Construction of Oxopolycyclic Systems, K.C. Nicolaou, C.-K. Hwang, M.E. Duggan, K. Bal Reddy, B.E. Marron, D.G. McGarry, J. Am. Chem. Soc. 1986, 108, 6800–6802.

150. Evidence for a 5(6)-Epoxy-Tetraene Intermediate in the Biosynthesis of Lipoxins in Human Leukocytes:  Conversion into Lipoxin by Cytosolic Epoxide Hydrolase, T.J. Puustinen, W.E. Webber, K.C. Nicolaou, J. Haeggstrom, C.N. Serhan, B. Samuelsson, FEBS Lett. 1986, 207, 127–132.

151. Stereoselective Total Synthesis of the Presumed Biosynthetic Precursor to Lipoxins A and B:  Methyl (7E, 9E, 11Z, 13E, 5S, 6S, 15S)-5,6-Epoxy-15-hydroxyicosa-7,9,11,13-tetraenoate and its 5,6-Methano Analogue, K.C. Nicolaou, S.E. Webber, J. Chem. Soc., Chem. Commun. 1986,1816–1817.

152. Synthesis of Eicosanoids, K.C. Nicolaou, N.A. Petasis, in Handbook of Eicosanoids, Prostaglandins and Related Lipids, Part B (Chemical and Biochemical Aspects), A.L. Willis, Ed., CRC Press, Boca Raton, Florida, 1987, pp. 1–18.

153. Organoselenium-Based Ring Closure Reactions, K.C. Nicolaou, N.A. Petasis, D.A. Claremon, in Organoselenium Chemistry, D. Liotta, Ed., John Wiley & Sons, New York, 1987, pp. 127–162.

154. Lipoxins A Induced Inhibition of Human Natural Killer Cell Cytotoxicity:  Studies on Stereospecificity of Inhibition and Mode of Action, U. Ramstedt, C.N. Serhan, K.C. Nicolaou, S.E. Webber, H. Wigzell, B. Samuelsson, J. Immun. 1986, 138, 266–270.

155. Stereocontrolled Construction of Key Building Blocks for the Total Synthesis of Amphoteronolide B and Amphotericin B, K.C. Nicolaou, R.A. Daines, J. Uenishi, W.S. Li, D.P. Papahatjis, T.K. Chakraborty, J. Am. Chem. Soc. 1987, 109, 2205–2208.

156. Total Synthesis of Amphoteronolide B, K.C. Nicolaou, R.A. Daines, T.K. Chakraborty, J. Am. Chem. Soc. 1987, 109, 2208–2210.

157. Total Synthesis of Amphotericin B, K.C. Nicolaou, R.A. Daines, T.K. Chakraborty, Y. Ogawa, J. Am. Chem. Soc. 1987, 109, 2821–2822.

158. Amphoteronolide B Methylester.  Novel Oxidative Deglycosidation of Amphotericin B, K.C. Nicolaou, T.K. Chakraborty, R.A. Daines, Y. Ogawa, J. Chem. Soc., Chem. Commun. 1987, 686–689.

159. Nucleophilic Additions to Thionolactones.  New Synthetic Technology for the Construction of Medium and Large Ring Ethers, K.C. Nicolaou, D.G. McGarry, C.A. Veale, P.K. Somers, J. Am. Chem. Soc. 1987, 109, 2504–2506.

160. Thermal Cycloadditions of Dimethyl Acetylenedicarboxylate with Cyclic Enolethers.  An Entry into Medium Size Oxocyclic Systems, K.C. Nicolaou, C.-K. Hwang, M.E. Duggan, K. Bal Reddy, Tetrahedron Lett. 1987, 28, 1501–1502.

161. Stereochemistry and Biosynthesis of Lipoxins, C.N. Serhan, K.C. Nicolaou, S.E. Webber, C.A. Veale, J. Haeggstrom, T.J. Puustinen, B. Samuelsson, Adv. Prost. Thromb. & Leukot. Res., B. Samuelsson, R. Paoletti, P.W. Ramwell, Eds., Raven Press, New York, Vol. 17A, 1987, pp. 90–93.

162. The Effects of Lipoxin A and Lipoxin B on Functional Responses of Human Granulocytes, J. Palmblad, H. Gyllenhammar, B. Ringertz, C.N. Serhan, B. Samuelsson, K.C. Nicolaou, Biochem. Biophys. Res. Commun. 1987, 145, 168–175.

163. The Action of Lipoxin-A on Glomerular Microcirculatory Dynamics in The Rat, K.F. Badr, C.N. Serhan, K.C. Nicolaou, B. Samuelsson, Biochem. Biophys. Res. Commun. 1987, 145, 408–414.

164. Dithiatopazine.  The First Stable 1,2-Dithietane, K.C. Nicolaou, C.-K. Hwang, M.E. Duggan, P.J. Carroll, J. Am. Chem. Soc. 1987, 109, 3801–3802.

165. Stereocontrolled Total Synthesis of Lipoxins A5 and B5, K.C. Nicolaou, S.E. Webber, J. Ramphal, Y. Abe, Angew. Chem. Int. Ed. Engl. 1987, 26, 1019–1021.

166. The Total Synthesis of the Lipoxins and Related Compounds, S.E. Webber, C.A. Veale, K.C. Nicolaou, in Advances in Experimental Medicine and Biology, P.Y. Wong and C.N. Serhan, Eds., Proc. FASEB Symp. on Lipoxins: Biosynthesis and Pharmacology, Plenum Press, New York, Vol. 229, 1987, 61–77.

167. Synthetic Eicosanoids, K.C. Nicolaou, N.A. Petasis, in Biology and Chemistry of Prostaglandins and Related Eicosanoids, P.B. Curtis-Prior, Ed., Churchill Livingstone, Edinburgh, 1988, pp. 78–94.

168. Preparation and Reactions of Glycosyl Fluorides, J.L. Randall, K.C. Nicolaou, in Fluorinated Carbohydrates, Chemical and Biochemical Aspects, ACS Symposium Series, N.F. Taylor, Ed., Vol. 374, 1988, Ch. 2, pp. 13–28.

169. Chemistry of Amphotericin B. Degradation Studies and Preparation of Amphoteronolide B, K.C. Nicolaou, T.K. Chakraborty, Y. Ogawa, R.A. Daines, N.S. Simpkins, G.T. Furst, J. Am. Chem. Soc. 1988, 110, 4660–4672.

170. Total Synthesis of Amphoteronolide B and Amphotericin B. 1. Strategy and Stereocontrolled Construction of Key Building Blocks, K.C. Nicolaou, R.A. Daines, J. Uenishi, W.S. Li, D.P. Papahatjis, T.K. Chakraborty, J. Am. Chem. Soc. 1988, 110, 4672–4685.

171. Total Synthesis of Amphoteronolide B and Amphotericin B. 2. Total Synthesis of Amphoteronolide B, K.C. Nicolaou, R.A. Daines, T.K. Chakraborty, J. Am. Chem. Soc. 1988, 110, 4685–4696.

172. Total Synthesis of Amphotericin B. 3. The Final Stages, K.C. Nicolaou, R.A. Daines, Y. Ogawa, T.K. Chakraborty, J. Am. Chem. Soc. 1988, 110, 4696–4705.

173. Cyclic Conjugated Enediynes Related to Calicheamicins and Esperamicins:  Calculations, Synthesis and Properties, K.C. Nicolaou, G. Zuccarello, Y. Ogawa, E.J. Schweiger, T. Kumazawa, J. Am. Chem. Soc. 1988, 110, 4866–4868.

174. Methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methyl-benzoate:  The Aromatic Fragment of Calichemicin g1aI. Synthesis, X-Ray Crystallographic Analysis and Properties, K.C. Nicolaou, T. Ebata, N.A. Stylianides, R.D. Groneberg, P.J. Carroll, Angew. Chem. Int. Ed. Engl. 1988, 27, 1097–1099.

175. Novel Chemistry of Dithiatopazine, K.C. Nicolaou, C.-K. Hwang, S. DeFrees, N.A. Stylianides, J. Am. Chem. Soc. 1988, 110, 4868–4869.

176. Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in vivo, S.E. Dahlen, L. Franzen, J. Raud, C.N. Serhan, P. Westlund, E. Wikstrom, T. Bjorck, H. Matsuda, S.E. Webber, C.A. Veale, T. Puustinen, J. Haeggstrom, K.C. Nicolaou, B. Samuelsson, in Lipoxins:  Biosynthesis, Chemistry and Biological Activities, P.Y.-K. Wong and C.N. Serhan, Eds., Plenum Press, New York, 1988, pp. 107–130.

177. DNA Cleavage by a Synthetic Mimic of the Calicheamicin-Esperamicin Class of Antibiotics, K.C. Nicolaou, Y. Ogawa, G. Zuccarello, H. Kataoka, J. Am. Chem. Soc. 1988, 110, 7247–7248.

178. A Practical and Enantioselective Synthesis of Glycosphingolipids and Related Compounds.  Total Synthesis of Globotriaosylceramide (Gb3), K.C. Nicolaou, T. Caulfield, H. Kataoka, T. Kumazawa, J. Am. Chem. Soc. 1988, 110, 7910–7912.

179. A Photolytic Entry into Oxepane Systems, K.C. Nicolaou, C.-K. Hwang, D.A. Nugiel, Angew. Chem. Int. Ed. Engl. 1988, 27, 1362–1364.

180. Lipoxins A4 and B4:  Comparison of Eicosanoids Having Bronchoconstrictor and Vasodilator Actions but Lacking Platelet Aggregatory Activity, A.M. Lefer, G.L. Stahl, D.J. Lefer, M.E. Brezinski, K.C. Nicolaou, C.A. Veale, Y. Abe, J.B. Smith, Proc. Natl. Acad. Sci. USA 1988, 85, 8340–8344.

181. Differential Effects of 20-Trifluoromethyl Leukotriene B4 on Human Neutrophil Functions, B.S. Tsai, R.H. Keith, D. Villani-Price, R.A. Haack, R.F. Bauer, R. Leonard, Y. Abe, K.C. Nicolaou, Prostaglandins 1989, 37, 287–302.

182. Identification of a Novel 7-cis-11-trans-lipoxin A4 Generated by Human Neutrophils:  Total Synthesis, Spasmogenic Activities, and Comparison with other Geometric Isomers of Lipoxin A4 and B4, K.C. Nicolaou, B.E. Marron, C.A. Veale, S.E. Webber, S.E. Dahlen, B. Samuelsson, Biochim. Biophys. Acta 1989, 1003, 44–53.

183. Cyclizations of Hydroxydithioketals.  New Synthetic Technology for the Construction of Oxocenes and Related Medium Ring Systems, K.C. Nicolaou, C.V.C. Prasad, C.-K. Hwang, M.E. Duggan, C.A. Veale, J. Am. Chem. Soc. 1989, 111, 5321–5330.

184. Activation of 6-endo over 5-exo Hydroxy Epoxide Openings.  Stereo- and Ringselective Synthesis of Tetrahydrofuran and Tetrahydropyran Systems, K.C. Nicolaou, C.V.C. Prasad, P.K. Somers, C.-K. Hwang, J. Am. Chem. Soc. 1989, 111, 5330–5334.

185. Activation of 7-endo over 6-exo Epoxide Openings.  Synthesis of Oxepane and Tetrahydropyran Systems, K.C. Nicolaou, C.V.C. Prasad, P.K. Somers, C.-K. Hwang, J. Am. Chem. Soc. 1989, 111, 5335–5340.

186. Pharmacologic Profile of Lipoxins A5 and B5:  New Biologically Active Eicosanoids, G.L. Stahl, P. Tsao, A.M. Lefer, J.Y. Ramphal, K.C. Nicolaou, Eur. J. Pharmacol. 1989, 163, 55–60.

187. A Synthetic Route to Forskolin, K.C. Nicolaou, S. Kubota, W.S. Li, J. Chem. Soc., Chem. Commun. 1989, 512–514.

188. Synthesis and Stereochemical Assignment of the C1-C10 Fragment of Nystatin A1,  K.C. Nicolaou, K.H. Ahn, Tetrahedron Lett. 1989, 30, 1217–1220.

189. Stereocontrolled Synthesis of the Sex Pheromone of the Green Stink Bug, K.C. Nicolaou, B.E. Marron, Synthesis 1989, 7, 537–540.

190. Synthetic Studies on the Dioxepane Region of Brevetoxin B.  New Synthetic Technology for the Construction of Oxepanes and Synthesis of a Model for the CDEF Ring Skeleton of Brevetoxin B, K.C. Nicolaou, C.-K. Hwang, D.A. Nugiel, J. Am. Chem. Soc. 1989, 111, 4136–4137.

191. Stereocontrolled Total Synthesis of (5S,6R)-, (5S,6S)-, (5R,6R)- and (5R,6S)- (7E,9E,11Z,14Z)-5,6-Dihydroxy-7,9,11,14-icosatetranoic Acid (5,6-DiHETE) Methyl Esters, K.C. Nicolaou, J.Y. Ramphal, J.M. Palazon, R.A. Spanevello, Angew. Chem. Int. Ed. Engl. 1989, 28, 587–588.

192. Synthesis of the ABC Ring System of Brevetoxin B, K.C. Nicolaou, M.E. Duggan, C.-K. Hwang, J. Am. Chem. Soc. 1989, 111, 6666–6675.

193. Synthesis of the FG Ring System of Brevetoxin B, K.C. Nicolaou, M.E. Duggan, C.-K. Hwang, J. Am. Chem. Soc. 1989, 111, 6676–6682.

194. Synthesis of the Brevetoxin B IJK Ring System, K.C. Nicolaou, C.-K. Hwang, M.E. Duggan, J. Am. Chem. Soc. 1989, 111, 6682–6690.

195. A New Class of DNA-Cleaving Molecules. pH-Dependent DNA Cleavage by Propargylic and Allenic Sulfones, K.C. Nicolaou, G. Skokotas, P. Maligres, G. Zuccarello, E.J. Schweiger, K. Toshima, S. Wendeborn, Angew. Chem. Int. Ed. Engl. 1989, 28, 1272–1275.

196. Pheromone Blends of Green Stink Bugs and Possible Parasitoid Selection, J.R. Aldrich, W.R. Lusby, B.E. Marron, K.C. Nicolaou, M.P. Hoffmann, L.T. Wilson, Naturwissenschaften 1989, 76, 173–175.

197. Synthesis of 19,19,20,20,20-Pentadeuterated Lipoxin A4 Methyl Ester and 19,19,20,20,20-Pentadeuterated Arachidonic Acid and Demonstration of Their Use in the Quantitative Detection of Naturally Occurring Eicosanoids, B.E. Marron, R.A. Spanevello, M.E. Elisseou, C.N. Serhan, K.C. Nicolaou, J. Org. Chem. 1989, 54, 5522–5527.

198. Total Synthesis of Novel Geometric Isomers of Lipoxins A4 and Lipoxin B4, K.C. Nicolaou, B.E. Marron, C.A. Veale, S.E. Webber, C.N. Serhan, J. Org. Chem. 1989, 54, 5527–5535.

199. Stereocontrolled Total Synthesis of Methyl 12(S)-Hydroxy-5Z,8E,10E-heptadecatrienoate, K.C. Nicolaou, N.A. Stylianides, J.Y. Ramphal, J. Chem. Soc., Perkin Trans. 1 1989, 2131–2132.

200. Lipoxin4 A Causes Generation of Thromboxane A2 in the Guinea-Pig Lung, E. Wikstrom, P. Westlund, K.C. Nicolaou, S.-E. Dahlen, Agents and Actions 1989, 26, 90–92.

201. Pharmacodynamics of Lipoxin A4 in Airway Smooth Muscle, S.-E. Dahlen, C.A. Veale, S.E. Webber, B.E. Marron, K.C. Nicolaou, C.N. Serhan, Agents and Actions 1989, 26, 93–95.

202. Lipoxin Stimulate Prostacyclic Generation by Human Endothelial Cells, M.E. Brezinski, M.A. Gimbrone, Jr., K.C. Nicolaou, C.N. Serhan, FEBS Lett. 1989, 245, 167–172.

203. Stereocontrolled Total Synthesis of 12(R)-Hydroxy-5Z, 8Z, 10E, 14Z-Eicosatetraenoic Acid [12(R)-HETE], K.C. Nicolaou, J. Ramphal, Y. Abe, Synthesis 1989, 12, 898–901.

204. Lipoxin A4 Inhibits Leukotriene B4-Induced Inflammation in the Hamster Cheek Pouch, P. Hedqvist, U. Palmertz, J. Haeggstrom, K.C. Nicolaou, S.-E. Dahlen, Acta Physiol. Scand. 1989, 137, 571–572.

205. Platelet-Activiting Factor PAF Antagonistic Actions of Two New Analogs of PAF, P.S. Tsao, G.A. Stahl, A.M. Lefer, J.M. Salvino, S. Pietranico, K.C. Nicolaou, J. Lipid Mediators 1989, 1, 189–199.

206. Aspects of Eicosanoids in Inflammation, P. Hedqvist, S.E. Dahlen, J. Raud, L. Lindbom, A. Thuresson-Klein, K.C. Nicolaou, NATO ASI Ser. A 1989, 177, 169–182.

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