Methodologies

Natural Product-like Combinatorial Libraries Based on Privileged Structures. General Principles and Solid-Phase Synthesis of Benzopyrans

Natural Product-like Combinatorial Libraries Based on Privileged Structures. The "Libraries from Libraries" Principle for Diversity Enhancement of Benzopyran Libraries

Novel IBX-Mediated Processes for the Synthesis of Amino-Sugars and Derivatives Thereof

A New Method for the One-Step Synthesis of alpha,beta-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds

An Unprecedented Titanocene Methylidene by which to Deoxygenate Sulfoxides and Selenoxides, as well as to Generate 2-Methylpyridines from the Corresponding N-Oxides

Use of a 5-exo-tet Cyclization Strategy to Prepare Trans-Disubstituted Benzofurans

New Synthetic Technology for the Mild and Selective One-Carbon Homologation of Hindered Aldehydes in the Presence of Ketones

New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin

Selenium-Based Solid-Phase Synthesis of Benzopyrans: Applications to Combinatorial Synthesis of Natural Products and Small Molecules

Solution and Solid-Phase Synthesis of Functionalized 3-Arylbenzofurans via a Novel Cyclofragmentation-Release Pathway

Solution and Solid Phase Synthesis of 2-Deoxyglycosides, Orthoesters, and Allylic Orthoesters via 1,2-Selenium Migrations

Studies Towards Trichodimerol: Novel Cascade Reactions and Polycyclic Frameworks

A Facile Method for the Solution and Solid-Phase Synthesis of Substituted [3.3.1] Bicycles

New Synthetic Technology for the Synthesis of Hindered alpha-Diazoketones via Acyl Mesylates

New Synthetic Technology for the Rapid Construction of Novel Heterocyles. 1. The Reaction of Dess-Martin Periodinane with Anilides and Related Compounds

Novel Chemistry en route to the CP Molecules: Unprecedented Construction of the Fused Maleic Anhydride Moiety

Novel Strategies to Construct the gamma-Hydroxy Lactone Moiety of the CP Molecules. Synthesis of the CP-225,917 Core Skeleton

Solid Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy. Application of the Stille Coupling to a Synthesis of (S)-Zearalenone

Synthesis of 16-Desmethylepothilone B: Improved Methodology for the Rapid, Highly Selective and Convergent Construction of Epothilone B and Analogs

Synthesis of N-Heterocycles via Lactam-Derived Ketene Aminal Phosphates. Asymmetric Synthesis of Cyclic Amino Acids

Polymer-Supported Selenium REagents for Organic Synthesis

A Novel Approach to the CP-225,917 and CP-263,114 Core

Solid Phase Synthesis of Oligosaccharides

Solid Phase Synthesis of Macrocycles

New Synthetic Technology for the Sterocontrolled Construction of 1,1'-Disaccharides. Synthesis of the FG Ring System of Everninomicin 13,384-1

A Suzuki Coupling-Macrolactamization Approach to the AB-COD Bicyclic System of Vancomycin

Asymmetric Synthesis of 3-Substituted 4-Oxoesters Using the SAMP-/RAMP-Hydrazone Method

Application of Ni0-Mediated C–C Coupling Strategy for the Synthesis of the Rigid 12-Membered Biaryl Ring System of the Vancomycin Antibiotics

Enol-Phosphates and Thioketal-Mediated Etherification for the Construction of EFGH Ring Skeleton of Brevetoxin A

The Oxide Anion Accelerated Retro-Diels-Alder Reaction Employed for the Synthesis of Enediynes

New Synthetic Technology for the Synthesis of Biaryl Ethers: Construction of C-O-D and D-O-E Ring Model Systems of Vancomycin

Cyclic Ketene Acetal Phosphates for the Construction of Meduim and Large Cyclic Ethers

Construction of Complex Polyether Frameworks Through the Cul-Promoted Stille Cross-Coupling of Stannyl Enol Ethers with Enol Triflates

Synthesis of Novel Heterocycles Related to the Dynemicin A Ring Skeleton

An Olefin Metathesis Based Strategy for the Construction of the JKL, OPQ and UVW Ring Systems of Maitotoxin

The Olefin Metathesis Strategy for the Synthesis of Epothilones

Photochemical Analog of the Bergman Cycloaromatization Reaction

Regioselective Carbonate Ring Opening Reaction

A General and Efficient Radical Desulfurization Converting Thionesters and Thionolactones to Ethers

Radiofrequency Encoded Combinatorial Chemistry (RECC)

Novel Stereocontrolled Synthesis of the Nonacene Ring System of Brevetoxin A. Conformational-Reactivity Effects in Nine-Membered Rings

New Strategy for the Synthesis of C-2 Taxol Analogs

Novel Methodology for the Construction of Enediynes

Photolytic Entry Into Oxepane Systems

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Research

Summaries of Research Accomplishments

Total Synthesis

Methodologies

Chemical Biology

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